MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1α) in the tumor microenvironments

MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1α) in the tumor microenvironments

MicroRNAs regulate most protein-coding genes, including genes important in cancer and other diseases. In this study, we demonstrated that the expression of miR-142 could be significantly suppressed in pancreatic cancer specimens and cell lines compared to their adjacent tissues and normal pancreatic...

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Bibliographic Details
Main Authors: Yebin Lu, Niandong Ji, Wei Wei, Weijia Sun, Xuejun Gong, Xitao Wang
Format: Article
Language:English
Published: The Company of Biologists 2017-02-01
Series:Biology Open
Subjects:
MiR-142
Pancreatic cancer
Cell proliferation
Cell invasion
HIF-1α
Hypoxia microenvironment
Online Access:http://bio.biologists.org/content/6/2/252

Internet

http://bio.biologists.org/content/6/2/252

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