Opposite Roles of Furin and PC5A in N-Cadherin Processing

We recently demonstrated that lack of Furin-processing of the N-cadherin precursor (proNCAD) in highly invasive melanoma and brain tumor cells results in the cell-surface expression of a nonadhesive protein favoring cell migration and invasion in vitro. Quantitative polymerase chain reaction analys...

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Bibliographic Details
Main Authors: Deborah Maret, Mohamad Seyed Sadr, Emad Seyed Sadr, David R Colman, Rolando F Del Maestro, Nabil G Seidah
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612800200