RNAi silencing of P/Q-type calcium channels in Purkinje neurons of adult mouse leads to episodic ataxia type 2

RNAi silencing of P/Q-type calcium channels in Purkinje neurons of adult mouse leads to episodic ataxia type 2

Episodic ataxia type-2 (EA2) is a dominantly inherited human neurological disorder caused by loss of function mutations in the CACNA1A gene, which encodes the CaV2.1 subunit of P/Q-type voltage-gated calcium channels. It remains however unknown whether the deficit of cerebellar CaV2.1 in adult is in...

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Bibliographic Details
Main Authors: Julie Salvi, Federica Bertaso, Anne-Laure Mausset-Bonnefont, Alexandra Metz, Céline Lemmers, Fabrice Ango, Laurent Fagni, Philippe Lory, Alexandre Mezghrani
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Neurobiology of Disease
Subjects:
P/Q-type calcium channel
Mouse
Cerebellum
Purkinje neuron
RNA interference
Ataxia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000941

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http://www.sciencedirect.com/science/article/pii/S0969996114000941

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