Rhesus Cytomegalovirus-Specific CD8+ Cytotoxic T Lymphocytes Do Not Become Functionally Exhausted in Chronic SIVmac239 Infection

Rhesus Cytomegalovirus-Specific CD8+ Cytotoxic T Lymphocytes Do Not Become Functionally Exhausted in Chronic SIVmac239 Infection

CD8+ cytotoxic T lymphocytes (CTLs) exert potent antiviral activity after HIV/SIV infection. However, efforts to harness the antiviral efficacy of CTLs for HIV/SIV prophylaxis and therapy have been severely hindered by two major problems: viral escape and exhaustion. By contrast, CTLs directed again...

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Bibliographic Details
Main Authors: Brandon C. Rosen, Nuria Pedreño-Lopez, Michael J. Ricciardi, Jason S. Reed, Jonah B. Sacha, Eva G. Rakasz, David I. Watkins
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
simian immunodeficiency virus
cytotoxic T lymphocytes
cytomegalovirus
rhesus macaques
human immunodeficiency virus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01960/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01960/full

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