GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons.

GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons.

The PI3K-dependent activation of AKT results in the inhibition of GSK3β in most signaling pathways. These kinases regulate multiple neuronal processes including the control of synapse number as shown for Drosophila and rodents. Alzheimer disease's patients exhibit high levels of circulating GSK...

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Bibliographic Details
Main Authors: Germán Cuesto, Sheila Jordán-Álvarez, Lilian Enriquez-Barreto, Alberto Ferrús, Miguel Morales, Ángel Acebes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4357437?pdf=render

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http://europepmc.org/articles/PMC4357437?pdf=render

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