GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons.
The PI3K-dependent activation of AKT results in the inhibition of GSK3β in most signaling pathways. These kinases regulate multiple neuronal processes including the control of synapse number as shown for Drosophila and rodents. Alzheimer disease's patients exhibit high levels of circulating GSK...
Main Authors: | Germán Cuesto, Sheila Jordán-Álvarez, Lilian Enriquez-Barreto, Alberto Ferrús, Miguel Morales, Ángel Acebes |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4357437?pdf=render |
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