High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors

Hsp90 has become the target of intensive investigation, as inhibition of its function has the ability to simultaneously incapacitate proteins that function in pathways that represent the six hallmarks of cancer. While a number of Hsp90 inhibitors have made it into clinical trials, a number of short-...

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Bibliographic Details
Main Authors: Jason Davenport, Maurie Balch, Lakshmi Galam, Antwan Girgis, Jessica Hall, Brian S. J. Blagg, Robert L. Matts
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Biology
Subjects:
Online Access:http://www.mdpi.com/2079-7737/3/1/101