Nuclear SMAD2 Restrains Proliferation of Glioblastoma

Aims: Although TGFβ receptor signaling has been shown to play a role in regulation of the growth and metastasis of glioblastoma multiforme (GBM), the downstream pathway through either SMAD2 or SMAD3 has not been elucidated. In this study, we investigate whether nuclear SMAD2 can restrain the prolife...

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Bibliographic Details
Main Authors: Yunhu Yu, Qishan Ran
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
p21
Online Access:http://www.karger.com/Article/FullText/373987