Marine-Derived Natural Products as ATP-Competitive mTOR Kinase Inhibitors for Cancer Therapeutics

Marine-Derived Natural Products as ATP-Competitive mTOR Kinase Inhibitors for Cancer Therapeutics

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase portraying a quintessential role in cellular proliferation and survival. Aberrations in the mTOR signaling pathway have been reported in numerous cancers including thyroid, lung, gastric and ovarian cancer, thus making it a therap...

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Bibliographic Details
Main Authors: Shraddha Parate, Vikas Kumar, Gihwan Lee, Shailima Rampogu, Jong Chan Hong, Keun Woo Lee
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceuticals
Subjects:
mTOR kinase
marine natural products
ATP-competitive inhibitors
structure-based pharmacophore modeling
virtual screening
molecular docking
Online Access:https://www.mdpi.com/1424-8247/14/3/282

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https://www.mdpi.com/1424-8247/14/3/282

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