Genome-Wide Small RNA Sequencing Identifies MicroRNAs Deregulated in Non-Small Cell Lung Carcinoma Harboring Gain-of-Function Mutant p53

Genome-Wide Small RNA Sequencing Identifies MicroRNAs Deregulated in Non-Small Cell Lung Carcinoma Harboring Gain-of-Function Mutant p53

Mutations in the <i>TP53</i> gene are one of the most frequent events in cancers. Certain missense mutant p53 proteins gain oncogenic functions (gain-of-functions) and drive tumorigenesis. Apart from the coding genes, a few non-coding microRNAs (miRNAs) are implicated in mediating mutant...

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Bibliographic Details
Main Authors: Arindam Datta, Pijush Das, Sanjib Dey, Sangeeta Ghuwalewala, Dishari Ghatak, Sk. Kayum Alam, Raghunath Chatterjee, Susanta Roychoudhury
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Genes
Subjects:
microrna
non-small cell lung carcinoma
mutant p53
gain of function
small rna sequencing
tcga
novel mirna
node metastasis
survival
Online Access:https://www.mdpi.com/2073-4425/10/11/852

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https://www.mdpi.com/2073-4425/10/11/852

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