Three-fold effect of lovastatin treatment on low density lipoprotein metabolism in subjects with hyperlipidemia: increase in receptor activity, decrease in apoB production, and decrease in particle affinity for the receptor. Results from a novel triple-tracer approach

Three-fold effect of lovastatin treatment on low density lipoprotein metabolism in subjects with hyperlipidemia: increase in receptor activity, decrease in apoB production, and decrease in particle affinity for the receptor. Results from a novel triple-tracer approach

To differentiate effects of lovastatin on low density lipoprotein (LDL) receptor activity from effects on LDL metabolic properties, LDL apolipoprotein B (apoB) turnover was studied in eight hyperlipidemic subjects during baseline and lovastatin treatment, in the latter case with LDL tracers isolated...

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Bibliographic Details
Main Authors: Lars Berglund, Joseph L. Witztum, Narmer F. Galeano, Andrew S. Khouw, Henry N. Ginsberg, Rajasekhar Ramakrishnan
Format: Article
Language:English
Published: Elsevier 1998-04-01
Series:Journal of Lipid Research
Subjects:
HMG-CoA reductase inhibitors
LDL receptor
apolipoprotein B
lipoprotein metabolism
tracer kinetics
lipid-lowering therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520325773

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http://www.sciencedirect.com/science/article/pii/S0022227520325773

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