Platelet Depletion is Effective in Ameliorating Anxiety-Like Behavior and Reducing the Pro-Inflammatory Environment in the Hippocampus in Murine Experimental Autoimmune Encephalomyelitis

Platelet Depletion is Effective in Ameliorating Anxiety-Like Behavior and Reducing the Pro-Inflammatory Environment in the Hippocampus in Murine Experimental Autoimmune Encephalomyelitis

The neuropsychiatric symptoms of multiple sclerosis (MS), such as anxiety and depression, can result from disease activity itself as well as psychological reaction to an unfavorable diagnosis. Accordingly, the literature reports evidence of increased anxiety-like behavior in experimental autoimmune...

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Bibliographic Details
Main Authors: Pece Kocovski, Xiangrui Jiang, Claretta S. D’Souza, Zhenjiang Li, Phuc T. Dang, Xiaowei Wang, Weisan Chen, Karlheinz Peter, Matthew W. Hale, Jacqueline M. Orian
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Journal of Clinical Medicine
Subjects:
platelets
neuroinflammation
EAE
EPM
hippocampus
MS
anxiety-like behavior
C57BL/6
autoimmune disease
MS therapy
Online Access:https://www.mdpi.com/2077-0383/8/2/162

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https://www.mdpi.com/2077-0383/8/2/162

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