Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response.

Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response.

BACKGROUND:Ascariasis remains the most common helminth infection in humans. As an alternative or complementary approach to global deworming, a pan-anthelminthic vaccine is under development targeting Ascaris, hookworm, and Trichuris infections. As16 and As14 have previously been described as two gen...

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Bibliographic Details
Main Authors: Junfei Wei, Leroy Versteeg, Zhuyun Liu, Brian Keegan, Ana Clara Gazzinelli-Guimarães, Ricardo T Fujiwara, Neima Briggs, Kathryn M Jones, Ulrich Strych, Coreen M Beaumier, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5529013?pdf=render

Internet

http://europepmc.org/articles/PMC5529013?pdf=render

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