The DNA damage response: a common pathway in the regulation of NKG2D and DNAM-1 ligand expression in normal, infected and cancer cells.

The DNA damage response: a common pathway in the regulation of NKG2D and DNAM-1 ligand expression in normal, infected and cancer cells.

NKG2D and DNAM-1 are two activating receptors, present on the surface of NK cells and other cells of the immune system. Their ligands – MICA, MICB, ULBP1-6 for NKG2D, PVR/CD155 and Nectin-2/CD112 for DNAM-1 - can be constitutively expressed at low levels in some normal cells, but they are more often...

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Bibliographic Details
Main Authors: Cristina eCerboni, Cinzia eFionda, Alessandra eSoriani, Alessandra eZingoni, Margherita eDoria, Marco eCippitelli, Angela eSantoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Immunology
Subjects:
NK cells
stress
DNA damage response
NKG2D ligands
DNAM-1 ligands
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00508/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00508/full

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