A Pathogenic Role for Splenic B1 Cells in SIV Disease Progression in Rhesus Macaques

A Pathogenic Role for Splenic B1 Cells in SIV Disease Progression in Rhesus Macaques

B1 cells spontaneously produce protective natural antibodies which provide the first line of defense against a variety of pathogens. Although these natural antibodies share similar autoreactive features with several HIV-1 broadly neutralizing antibodies, the role of B1 cells in HIV/SIV disease progr...

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Bibliographic Details
Main Authors: Gospel Enyindah-Asonye, Anthony Nwankwo, Christopher Hogge, Mohammad Arif Rahman, Sabrina Helmold Hait, Ruth Hunegnaw, Eun-Ju Ko, Tanya Hoang, David J. Venzon, Marjorie Robert-Guroff
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
B1 cells
rhesus macaque
simian immunodeficiency virus
exhaustion
T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00511/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00511/full

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