Sacubitril/Valsartan Reduces Fibrosis and Alleviates High-Salt Diet-Induced HFpEF in Rats

Sacubitril/Valsartan Reduces Fibrosis and Alleviates High-Salt Diet-Induced HFpEF in Rats

Previous studies have confirmed the clinical efficacy of sacubitril/valsartan (Sac/Val) for the treatment of heart failure with reduced ejection fraction (HFrEF). However, the role of Sac/Val in heart failure with preserved ejection fraction (HFpEF) remains unclear. Sac/Val is a combination therapeu...

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Bibliographic Details
Main Authors: Wenchao Zhang, Jianwei Liu, Yang Fu, Huifang Ji, Zheyan Fang, Wanming Zhou, Huimin Fan, Yingxuan Zhang, Yan Liao, Ting Yang, Xiaolin Wang, Wanwan Yuan, Xiaoshu Chen, Yi-fei Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
heart failure with preserved ejection fraction
vascular injury
sacubitril/valsartan
fibrosis
high-salt diet
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.600953/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.600953/full

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