A Cryptochrome 2 mutation yields advanced sleep phase in humans

A Cryptochrome 2 mutation yields advanced sleep phase in humans

Familial Advanced Sleep Phase (FASP) is a heritable human sleep phenotype characterized by very early sleep and wake times. We identified a missense mutation in the human Cryptochrome 2 (CRY2) gene that co-segregates with FASP in one family. The mutation leads to replacement of an alanine residue at...

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Bibliographic Details
Main Authors: Arisa Hirano, Guangsen Shi, Christopher R Jones, Anna Lipzen, Len A Pennacchio, Ying Xu, William C Hallows, Thomas McMahon, Maya Yamazaki, Louis J Ptáček, Ying-Hui Fu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
circadian clock
cryptochrome2
circadian rhythm
FBXL3
Familial Advanced Sleep Phase
Online Access:https://elifesciences.org/articles/16695

Internet

https://elifesciences.org/articles/16695

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