Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation*[S]

Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation*[S]

Obesity promotes insulin resistance and chronic inflammation. Disrupting any of several distinct steps in lipid synthesis decreases adiposity, but it is unclear if this approach coordinately corrects the environment that propagates metabolic disease. We tested the hypothesis that inactivation of FAS...

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Bibliographic Details
Main Authors: Manu V. Chakravarthy, Yimin Zhu, Li Yin, Trey Coleman, Kirk L. Pappan, Connie A. Marshall, Michael L. McDaniel, Clay F. Semenkovich
Format: Article
Language:English
Published: Elsevier 2009-04-01
Series:Journal of Lipid Research
Subjects:
metabolic syndrome
insulin resistance
type 2 diabetes mellitus
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520308609

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http://www.sciencedirect.com/science/article/pii/S0022227520308609

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