L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease

There is strong evidence that intracellular calcium dysregulation plays an important pathological role in Alzheimer's disease, and specifically that beta amyloid may induce increases in intracellular calcium and lead to neuronal cell dysfunction and death. Here we investigated the feasibility o...

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Bibliographic Details
Main Authors: Thimmappa S. Anekonda, Joseph F. Quinn, Christopher Harris, Kate Frahler, Teri L. Wadsworth, Randall L. Woltjer
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002925