Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors

Double conditional knockout of Meis1/2 in the limb forming region of mouse embryos results in the complete absence of limb, while embryos developed with one functional Meis allele, so identifying the role of Meis in antero-posterior and proximo-distal patterning.

Bibliographic Details
Main Authors: Irene Delgado, Giovanna Giovinazzo, Susana Temiño, Yves Gauthier, Aurelio Balsalobre, Jacques Drouin, Miguel Torres
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23373-9