Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors

Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors

Double conditional knockout of Meis1/2 in the limb forming region of mouse embryos results in the complete absence of limb, while embryos developed with one functional Meis allele, so identifying the role of Meis in antero-posterior and proximo-distal patterning.

Bibliographic Details
Main Authors: Irene Delgado, Giovanna Giovinazzo, Susana Temiño, Yves Gauthier, Aurelio Balsalobre, Jacques Drouin, Miguel Torres
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23373-9
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spelling doaj-136e8a5b878340a4a8a9d68369c894832021-05-30T11:15:28ZengNature Publishing GroupNature Communications2041-17232021-05-0112111310.1038/s41467-021-23373-9Control of mouse limb initiation and antero-posterior patterning by Meis transcription factorsIrene Delgado0Giovanna Giovinazzo1Susana Temiño2Yves Gauthier3Aurelio Balsalobre4Jacques Drouin5Miguel Torres6Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC)Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC)Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC)Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de MontréalLaboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de MontréalLaboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de MontréalCardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC)Double conditional knockout of Meis1/2 in the limb forming region of mouse embryos results in the complete absence of limb, while embryos developed with one functional Meis allele, so identifying the role of Meis in antero-posterior and proximo-distal patterning.https://doi.org/10.1038/s41467-021-23373-9
collection DOAJ
language English
format Article
sources DOAJ
author Irene Delgado
Giovanna Giovinazzo
Susana Temiño
Yves Gauthier
Aurelio Balsalobre
Jacques Drouin
Miguel Torres
spellingShingle Irene Delgado
Giovanna Giovinazzo
Susana Temiño
Yves Gauthier
Aurelio Balsalobre
Jacques Drouin
Miguel Torres
Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors
Nature Communications
author_facet Irene Delgado
Giovanna Giovinazzo
Susana Temiño
Yves Gauthier
Aurelio Balsalobre
Jacques Drouin
Miguel Torres
author_sort Irene Delgado
title Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors
title_short Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors
title_full Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors
title_fullStr Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors
title_full_unstemmed Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors
title_sort control of mouse limb initiation and antero-posterior patterning by meis transcription factors
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description Double conditional knockout of Meis1/2 in the limb forming region of mouse embryos results in the complete absence of limb, while embryos developed with one functional Meis allele, so identifying the role of Meis in antero-posterior and proximo-distal patterning.
url https://doi.org/10.1038/s41467-021-23373-9
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