A cytokine screen using CRISPR-Cas9 knock-in reporter pig iPS cells reveals that Activin A regulates NANOG

A cytokine screen using CRISPR-Cas9 knock-in reporter pig iPS cells reveals that Activin A regulates NANOG

Abstract Background NANOG functions as the gateway for the generation of pluripotent stem cells (PSCs) in mice and humans. NANOG is a transcription factor highly expressed in pig pre-implantation embryos, indicating that it is a conserved pluripotency-associated factor. However, pig NANOG reporter P...

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Bibliographic Details
Main Authors: Junjun Xu, Zheng Zheng, Xuguang Du, Bingbo Shi, Jichang Wang, Dengfeng Gao, Qianqian Zhu, Xinze Chen, Jianyong Han
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Stem Cell Research & Therapy
Subjects:
Pluripotency
CRISPR/Cas9
NANOG reporter
Cytokine screen
Activin A
Online Access:http://link.springer.com/article/10.1186/s13287-020-1588-z

Internet

http://link.springer.com/article/10.1186/s13287-020-1588-z

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