Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.

Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.

During the recent H1N1 outbreak, obese patients had worsened lung injury and increased mortality. We used a murine model of influenza A pneumonia to test the hypothesis that leptin receptor deficiency might explain the enhanced mortality in obese patients.We infected wild-type, obese mice globally d...

Full description

Bibliographic Details
Main Authors: Kathryn A Radigan, Luisa Morales-Nebreda, Saul Soberanes, Trevor Nicholson, Recep Nigdelioglu, Takugo Cho, Monica Chi, Robert B Hamanaka, Alexander V Misharin, Harris Perlman, G R Scott Budinger, Gökhan M Mutlu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4169489?pdf=render

Internet

http://europepmc.org/articles/PMC4169489?pdf=render

Similar Items