Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling

Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling

Abstract Background Baicalin, an important flavonoid in Scutellaria baicalensis Georgi extracts, exerts a variety of pharmacological effects. In this study, we explored the effects of baicalin on chronic hypoxia-induced pulmonary arterial hypertension (PAH) and investigated the mechanism underlying...

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Bibliographic Details
Main Authors: Xiaoying Huang, Peiliang Wu, Feifei Huang, Min Xu, Mayun Chen, Kate Huang, Guo-ping Li, Manhuan Xu, Dan Yao, Liangxing Wang
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Biomedical Science
Subjects:
Baicalin
Pulmonary arterial hypertension
Receptor
Adenosine A2A
SDF-1
CXCR4
Online Access:http://link.springer.com/article/10.1186/s12929-017-0359-3

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http://link.springer.com/article/10.1186/s12929-017-0359-3

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