Population Genomics of GII.4 Noroviruses Reveal Complex Diversification and New Antigenic Sites Involved in the Emergence of Pandemic Strains

Population Genomics of GII.4 Noroviruses Reveal Complex Diversification and New Antigenic Sites Involved in the Emergence of Pandemic Strains

Noroviruses are an important cause of viral gastroenteritis around the world. An obstacle delaying the development of norovirus vaccines is inadequate understanding of the role of norovirus diversity in immunity. Using a population genomics approach, we identified new residues on the viral capsid pr...

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Bibliographic Details
Main Authors: Kentaro Tohma, Cara J. Lepore, Yamei Gao, Lauren A. Ford-Siltz, Gabriel I. Parra
Format: Article
Language:English
Published: American Society for Microbiology 2019-09-01
Series:mBio
Subjects:
antigenic variation
caliciviruses
evolution
gastrointestinal infection
norovirus
phylogenetic analysis
Online Access:https://doi.org/10.1128/mBio.02202-19

Internet

https://doi.org/10.1128/mBio.02202-19

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