Evaluation of Somatic Hypermutation Status in Chronic Lymphocytic Leukemia (CLL) in the Era of Next Generation Sequencing

Evaluation of Somatic Hypermutation Status in Chronic Lymphocytic Leukemia (CLL) in the Era of Next Generation Sequencing

Somatic hypermutation (SHM) status provides an important prognostic indicator for chronic lymphocytic leukemia (CLL), a very common type of mature B-cell leukemia. Owing to the adverse prognosis associated with an unmutated immunoglobulin heavy chain variable (IGHV) status, SHM testing is performed...

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Bibliographic Details
Main Authors: Sanjeev Kumar Gupta, David S. Viswanatha, Keyur P. Patel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CLL
somatic hypermutation
NGS
clonality
immunoglobulin heavy chain
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00357/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00357/full

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