A novel mineralocorticoid receptor antagonist, 7,3',4'-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids

A novel mineralocorticoid receptor antagonist, 7,3',4'-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids

Abstract Excess glucocorticoids (GCs) with either endogenous or exogenous origins deteriorate skin barrier function. GCs bind to mineralocorticoid and GC receptors (MRs and GRs) in normal human epidermal keratinocytes (NHEKs). Inappropriate MR activation by GCs mediates various GC-induced cutaneous...

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Bibliographic Details
Main Authors: Hanil Lee, Eun-Jeong Choi, Eun Jung Kim, Eui Dong Son, Hyoung-June Kim, Won-Seok Park, Young-Gyu Kang, Kyong-Oh Shin, Kyungho Park, Jin-Chul Kim, Su-Nam Kim, Eung Ho Choi
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91450-6

Internet

https://doi.org/10.1038/s41598-021-91450-6

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