Combined Wnt/β-Catenin, Met, and CXCL12/CXCR4 Signals Characterize Basal Breast Cancer and Predict Disease Outcome

Combined Wnt/β-Catenin, Met, and CXCL12/CXCR4 Signals Characterize Basal Breast Cancer and Predict Disease Outcome

Prognosis for patients with estrogen-receptor (ER)-negative basal breast cancer is poor, and chemotherapy is currently the best therapeutic option. We have generated a compound-mutant mouse model combining the activation of β-catenin and HGF (Wnt-Met signaling), which produced rapidly growing basal...

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Bibliographic Details
Main Authors: Jane D. Holland, Balázs Györffy, Regina Vogel, Klaus Eckert, Giovanni Valenti, Liang Fang, Philipp Lohneis, Sefer Elezkurtaj, Ulrike Ziebold, Walter Birchmeier
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713006499

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http://www.sciencedirect.com/science/article/pii/S2211124713006499

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