Hypoxia-inducible transcription factor-1α inhibition by topotecan protects against lipopolysaccharide-induced inflammation and apoptosis of cardiomyocytes

Hypoxia-inducible transcription factor-1α inhibition by topotecan protects against lipopolysaccharide-induced inflammation and apoptosis of cardiomyocytes

Abstract Background Myocarditis, an inflammatory disease of the myocardium, is a serious hazard to human life due to the expansion of inflammatory lesions in the myocardium. The aim of this study was to investigate the role of hypoxia-inducible transcription factor (HIF)-1α and its inhibitor topotec...

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Bibliographic Details
Main Authors: Ying Zhang, Yi Xu, Ke Zhou, Guoying Kao, Meng Yan, Jun Xiao
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BioMedical Engineering OnLine
Subjects:
Myocarditis
Inflammation
Apoptosis
HIF-1α
Topotecan
Online Access:https://doi.org/10.1186/s12938-021-00923-2

Internet

https://doi.org/10.1186/s12938-021-00923-2

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