Asynchronous Cholinergic Drive Correlates with Excitation-Inhibition Imbalance via a Neuronal Ca2+ Sensor Protein

Asynchronous Cholinergic Drive Correlates with Excitation-Inhibition Imbalance via a Neuronal Ca2+ Sensor Protein

Excitation-inhibition imbalance in neural networks is widely linked to neurological and neuropsychiatric disorders. However, how genetic factors alter neuronal activity, leading to excitation-inhibition imbalance, remains unclear. Here, using the C. elegans locomotor circuit, we examine how altering...

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Bibliographic Details
Main Authors: Keming Zhou, Salvatore J. Cherra, III, Alexandr Goncharov, Yishi Jin
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
excitation-inhibition balance
presynaptic release kinetics
synaptic plasticity
epilepsy
asynchronous release
motor circuit
seizure
activity-dependent circuit modification
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717305375

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http://www.sciencedirect.com/science/article/pii/S2211124717305375

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