Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood

Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood

Age-related clonal hematopoiesis is associated with risk for diseases like acute myeloid leukemia (AML), yet it is unclear why some individuals do not progress despite having AML driver mutations. Here, the authors use deep learning and population genetics models to investigate how the interplay of...

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Bibliographic Details
Main Authors: Kimberly Skead, Armande Ang Houle, Sagi Abelson, Mawusse Agbessi, Vanessa Bruat, Boxi Lin, David Soave, Liran Shlush, Stephen Wright, John Dick, Quaid Morris, Philip Awadalla
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25172-8

Internet

https://doi.org/10.1038/s41467-021-25172-8

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