Hematopoietic Stem and Progenitor Cells Are a Distinct HIV Reservoir that Contributes to Persistent Viremia in Suppressed Patients

Hematopoietic Stem and Progenitor Cells Are a Distinct HIV Reservoir that Contributes to Persistent Viremia in Suppressed Patients

Summary: Long-lived reservoirs of persistent HIV are a major barrier to a cure. CD4+ hematopoietic stem and progenitor cells (HSPCs) have the capacity for lifelong survival, self-renewal, and the generation of daughter cells. Recent evidence shows that they are also susceptible to HIV infection in v...

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Bibliographic Details
Main Authors: Thomas D. Zaikos, Valeri H. Terry, Nadia T. Sebastian Kettinger, Jay Lubow, Mark M. Painter, Maria C. Virgilio, Andrew Neevel, Frances Taschuk, Adewunmi Onafuwa-Nuga, Lucy A. McNamara, James Riddell, IV, Dale Bixby, Norman Markowitz, Kathleen L. Collins
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718319107

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http://www.sciencedirect.com/science/article/pii/S2211124718319107

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