Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration

Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration

Abstract Background Primary brain tumors, in particular glioblastoma (GBM), remain among the most challenging cancers. Like most malignant tumors, GBM is characterized by hypoxic stress that triggers paracrine, adaptive responses, such as angiogenesis and macrophage recruitment, rescuing cancer cell...

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Bibliographic Details
Main Authors: Svenja Offer, Julien A. Menard, Julio Enríquez Pérez, Kelin G. de Oliveira, Vineesh Indira Chandran, Maria C. Johansson, Anna Bång-Rudenstam, Peter Siesjö, Anna Ebbesson, Ingrid Hedenfalk, Pia C. Sundgren, Anna Darabi, Mattias Belting
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioma
Lipid metabolism
Hypoxia
Angiogenesis
Macrophages
Online Access:http://link.springer.com/article/10.1186/s13046-019-1228-6

Internet

http://link.springer.com/article/10.1186/s13046-019-1228-6

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