Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice

Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice

The role of microglia recruited from bone marrow (BM) into the CNS during the progression of Alzheimer's disease (AD) is poorly understood. To investigate whether β-amyloid (Aβ) associated microglia are derived from blood monocytes, we transplanted BM cells from enhanced green fluorescent prote...

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Bibliographic Details
Main Authors: Tarja M. Malm, Milla Koistinaho, Maria Pärepalo, Tero Vatanen, Andreas Ooka, Stefan Karlsson, Jari Koistinaho
Format: Article
Language:English
Published: Elsevier 2005-02-01
Series:Neurobiology of Disease
Subjects:
Microglia
β-amyloid
Alzheimer's disease
Transgenic
Bone marrow
Transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002189

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http://www.sciencedirect.com/science/article/pii/S0969996104002189

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