Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice
The role of microglia recruited from bone marrow (BM) into the CNS during the progression of Alzheimer's disease (AD) is poorly understood. To investigate whether β-amyloid (Aβ) associated microglia are derived from blood monocytes, we transplanted BM cells from enhanced green fluorescent prote...
Main Authors: | Tarja M. Malm, Milla Koistinaho, Maria Pärepalo, Tero Vatanen, Andreas Ooka, Stefan Karlsson, Jari Koistinaho |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2005-02-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996104002189 |
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