Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis

Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis

The contributions of coagulation factor XI (FXI) and FXII to human clot formation is not fully known. Patients with deficiency in FXI have a variable mild bleeding risk, whereas FXII deficiency is not associated with bleeding. These phenotypes make FXII and FXI attractive target proteins in anticoag...

Full description

Bibliographic Details
Main Authors: José W. P. Govers-Riemslag, Joke Konings, Judith M. E. M. Cosemans, Johanna P. van Geffen, Bas de Laat, Johan W. M. Heemskerk, Yesim Dargaud, Hugo ten Cate
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2019-07-01
Series:TH Open
Subjects:
clot lysis
factor xii
factor xi
deficiency
thrombus formation
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1693485

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1693485

Similar Items