Association of CYP2D6 polymorphisms and extrapyramidal symptoms in schizophrenia patients receiving risperidone: a retrospective study

Association of CYP2D6 polymorphisms and extrapyramidal symptoms in schizophrenia patients receiving risperidone: a retrospective study

Abstract Background Risperidone is mainly metabolized by cytochrome P450 (CYP) 2D6 in the liver. The gene encoding CYP2D6 is highly polymorphic. The average steady-state plasma concentration of risperidone active moiety is higher in the CYP2D6 intermediate metabolizers (IMs) compared with that in th...

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Bibliographic Details
Main Authors: Takahiro Ito, Kazuhiro Yamamoto, Fuminori Ohsawa, Ikuo Otsuka, Akitoyo Hishimoto, Ichiro Sora, Midori Hirai, Ikuko Yano
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Schizophrenia
Extrapyramidal symptoms
DIEPSS
CYP2D6
Risperidone
Online Access:http://link.springer.com/article/10.1186/s40780-018-0126-y

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http://link.springer.com/article/10.1186/s40780-018-0126-y

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