Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data

Single-cell responses are shaped by the geometry of signalling kinetic trajectories carved in a multidimensional space spanned by signalling protein abundances. It is, however, challenging to assay a large number (more than 3) of signalling species in live-cell imaging, which makes it difficult to p...

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Bibliographic Details
Main Authors: Sayak Mukherjee, David Stewart, William Stewart, Lewis L. Lanier, Jayajit Das
Format: Article
Language:English
Published: The Royal Society 2017-01-01
Series:Royal Society Open Science
Subjects:
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.170811