Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells
Oncogenic mutations in PIK3CA lead to an increase in intrinsic phosphoinositide kinase activity, but it is thought that increased access of PI3Kα (phosphoinositide 3-kinase α) to its PM (plasma membrane) localized substrate is also required for increased levels of downstream PIP3/Akt [phosphoinosit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Portland Press, Biochemical Society
2014-04-01
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| Series: | Bioscience Reports |
| Subjects: | |
| Online Access: | http://www.bioscirep.org/bsr/034/e104/bsr034e104.htm |