3D-microtissue derived secretome as a cell-free approach for enhanced mineralization of scaffolds in the chorioallantoic membrane model

Abstract Bone regeneration is a complex process and the clinical translation of tissue engineered constructs (TECs) remains a challenge. The combination of biomaterials and mesenchymal stem cells (MSCs) may enhance the healing process through paracrine effects. Here, we investigated the influence of...

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Bibliographic Details
Main Authors: Lukas Otto, Petra Wolint, Annina Bopp, Anna Woloszyk, Anton S. Becker, Andreas Boss, Roland Böni, Maurizio Calcagni, Pietro Giovanoli, Simon P. Hoerstrup, Maximilian Y. Emmert, Johanna Buschmann
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-84123-x