Inhibiting RIPK1 Limits Neuroinflammation and Alleviates Postoperative Cognitive Impairments in D-Galactose-Induced Aged Mice

Inhibiting RIPK1 Limits Neuroinflammation and Alleviates Postoperative Cognitive Impairments in D-Galactose-Induced Aged Mice

Neuroinflammation plays a critical role in the pathogenesis of postoperative cognitive dysfunction (POCD) of the elderly patients. Receptor-interacting protein kinase1 (RIPK1) is a key molecular switch modulating inflammation, apoptosis and necroptosis. Here, we investigated whether inhibiting RIPK1...

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Bibliographic Details
Main Authors: Shangchun Duan, Xueqin Wang, Gong Chen, Chengxuan Quan, Shuangquan Qu, Jianbin Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
surgery
cognitive deficit
neuroinflammation
necrostatin-1
elderly
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00138/full

Internet

https://www.frontiersin.org/article/10.3389/fnbeh.2018.00138/full

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