Intestinal Phospholipid Disequilibrium Initiates an ER Stress Response That Drives Goblet Cell Necroptosis and Spontaneous Colitis in MiceSummary

Intestinal Phospholipid Disequilibrium Initiates an ER Stress Response That Drives Goblet Cell Necroptosis and Spontaneous Colitis in MiceSummary

Background & Aims: Patients with ulcerative colitis have low concentrations of the major membrane lipid phosphatidylcholine (PC) in gastrointestinal mucus, suggesting that defects in colonic PC metabolism might be involved in the development of colitis. To determine the precise role that PC...

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Bibliographic Details
Main Authors: John P. Kennelly, Stephanie Carlin, Tingting Ju, Jelske N. van der Veen, Randal C. Nelson, Jean Buteau, Aducio Thiesen, Caroline Richard, Ben P. Willing, René L. Jacobs
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Phosphatidylcholine
Inflammation
Colon
Mouse Model
Lipid
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20301855

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http://www.sciencedirect.com/science/article/pii/S2352345X20301855

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