Intestinal Phospholipid Disequilibrium Initiates an ER Stress Response That Drives Goblet Cell Necroptosis and Spontaneous Colitis in MiceSummary
Background & Aims: Patients with ulcerative colitis have low concentrations of the major membrane lipid phosphatidylcholine (PC) in gastrointestinal mucus, suggesting that defects in colonic PC metabolism might be involved in the development of colitis. To determine the precise role that PC...
Main Authors: | John P. Kennelly, Stephanie Carlin, Tingting Ju, Jelske N. van der Veen, Randal C. Nelson, Jean Buteau, Aducio Thiesen, Caroline Richard, Ben P. Willing, René L. Jacobs |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
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Series: | Cellular and Molecular Gastroenterology and Hepatology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X20301855 |
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