Cyclophilin A/EMMPRIN Axis Is Involved in Pro-Fibrotic Processes Associated with Thoracic Aortic Aneurysm of Marfan Syndrome Patients

Cyclophilin A/EMMPRIN Axis Is Involved in Pro-Fibrotic Processes Associated with Thoracic Aortic Aneurysm of Marfan Syndrome Patients

Background: Marfan syndrome (MFS) is a genetic disease, characterized by thoracic aortic aneurysm (TAA), which treatment is to date purely surgical. Understanding of novel molecular targets is mandatory to unveil effective pharmacological approaches. Cyclophilin A (CyPA) and its receptor EMMPRIN are...

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Bibliographic Details
Main Authors: Gianluca L. Perrucci, Erica Rurali, Maria Corlianò, Maria Balzo, Michela Piccoli, Donato Moschetta, Alessandro Pini, Raffaella Gaetano, Carlo Antona, Gustavo Egea, Gunter Fischer, Miroslav Malešević, Francesco Alamanni, Elisa Cogliati, Adolfo Paolin, Giulio Pompilio, Patrizia Nigro
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
thoracic aortic aneurysm
emmprin
fibrosis
vascular smooth muscle cells
cyclophilin a
Online Access:https://www.mdpi.com/2073-4409/9/1/154

Internet

https://www.mdpi.com/2073-4409/9/1/154

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