Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs

Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs

Whether aged hematopoietic stem and progenitor cells (HSPCs) have impaired DNA damage repair is controversial. Using a combination of DNA mutation indicator assays, we observe a 2- to 3-fold increase in the number of DNA mutations in the hematopoietic system upon aging. Young and aged hematopoietic...

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Bibliographic Details
Main Authors: Bettina M. Moehrle, Kalpana Nattamai, Andreas Brown, Maria C. Florian, Marnie Ryan, Mona Vogel, Corinna Bliederhaeuser, Karin Soller, Daniel R. Prows, Amir Abdollahi, David Schleimer, Dagmar Walter, Michael D. Milsom, Peter Stambrook, Matthew Porteus, Hartmut Geiger
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715013455

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http://www.sciencedirect.com/science/article/pii/S2211124715013455

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