IGFBP-4 Anti-Angiogenic and Anti-Tumorigenic Effects Are Associated with Anti-Cathepsin B Activity

IGFBP-4 Anti-Angiogenic and Anti-Tumorigenic Effects Are Associated with Anti-Cathepsin B Activity

Insulin-like growth factor-binding protein 4 (IGFBP-4/IBP-4) has potent IGF-independent anti-angiogenic and antitumorigenic effects. In this study, we demonstrated that these activities are located in the IGFBP-4 C-terminal protein fragment (CIBP-4), a region containing a thyroglobulin type 1 (Tg1)...

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Bibliographic Details
Main Authors: María J Moreno, Marguerite Ball, Marina Rukhlova, Jacqueline Slinn, Denis L'Abbe, Umar Iqbal, Robert Monette, Martin Hagedorn, Maureen D O'Connor-McCourt, Yves Durocher, Danica B Stanimirovic
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800413

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http://www.sciencedirect.com/science/article/pii/S1476558613800413

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