Towards Autonomous Operation by Advanced Process Control—Process Analytical Technology for Continuous Biologics Antibody Manufacturing

Towards Autonomous Operation by Advanced Process Control—Process Analytical Technology for Continuous Biologics Antibody Manufacturing

Continuous manufacturing opens up new operation windows with improved product quality in contrast to documented lot deviations in batch or fed-batch operations. A more sophisticated process control strategy is needed to adjust operation parameters and keep product quality constant during long-term o...

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Bibliographic Details
Main Authors: Heribert Helgers, Axel Schmidt, Lara Julia Lohmann, Florian Lukas Vetter, Alex Juckers, Christoph Jensch, Mourad Mouellef, Steffen Zobel-Roos, Jochen Strube
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Processes
Subjects:
quality by design (QbD)
process analytical technology (PAT)
digital twin
chemometrics
multivariate data analysis
continuous manufacturing
Online Access:https://www.mdpi.com/2227-9717/9/1/172

Internet

https://www.mdpi.com/2227-9717/9/1/172

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