Amyloid-β Homeostasis Bridges Inflammation, Synaptic Plasticity Deficits and Cognitive Dysfunction in Multiple Sclerosis

Amyloid-β Homeostasis Bridges Inflammation, Synaptic Plasticity Deficits and Cognitive Dysfunction in Multiple Sclerosis

Cognitive deficits are frequently observed in multiple sclerosis (MS), mainly involving processing speed and episodic memory. Both demyelination and gray matter atrophy can contribute to cognitive deficits in MS. In recent years, neuroinflammation is emerging as a new factor influencing clinical cou...

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Bibliographic Details
Main Authors: Mario Stampanoni Bassi, Sara Garofalo, Girolama A. Marfia, Luana Gilio, Ilaria Simonelli, Annamaria Finardi, Roberto Furlan, Giulia M. Sancesario, Jonny Di Giandomenico, Marianna Storto, Francesco Mori, Diego Centonze, Ennio Iezzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
amyloid-β
hippocampus
synaptic plasticity
inflammatory cytokines
IL-8
IL-10
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00390/full

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http://journal.frontiersin.org/article/10.3389/fnmol.2017.00390/full

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