Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation

Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation

Lipid droplet (LD) coating proteins are essential for the formation and stability of intracellular LDs. Plin2 is an abundant LD coating protein in skeletal muscle, but its importance for muscle function is unclear. We show that myotubes established from Plin2−/− mice contain reduced content of LDs a...

Full description

Bibliographic Details
Main Authors: Yuan Z. Feng, Jenny Lund, Yuchuan Li, Irlin K. Knabenes, Siril S. Bakke, Eili T. Kase, Yun K. Lee, Alan R. Kimmel, G. Hege Thoresen, Arild Christian Rustan, Knut Tomas Dalen
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Journal of Lipid Research
Subjects:
Plin2
triacylglycerol
lipid droplet
lipolysis and fatty acid metabolism
fatty acid/metabolism
insulin signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520338050

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520338050

Similar Items