Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy

Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy

Background: Minority drug resistance mutations (DRMs) that are often missed by Sanger sequencing are clinically significant, as they can cause virologic failure in individuals treated with antiretroviral therapy (ART) drugs. Objective: This study aimed to estimate the prevalence of minor DRMs among...

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Bibliographic Details
Main Authors: Zhiyong Zhou, Kevin Tang, Guoqing Zhang, Nellie Wadonda-Kabondo, Kundai Moyo, Lori A. Rowe, Joshua R. DeVos, Nick Wagar, Du-Ping Zheng, Hongxiong Guo, John Nkengasong, Mike Frace, Scott Sammons, Chunfu Yang
Format: Article
Language:English
Published: AOSIS 2018-05-01
Series:African Journal of Laboratory Medicine
Subjects:
deep sequencing
HIV-1 subtype C
ART-naïve
virologic failure
minority DR variants
Malawi
Online Access:https://ajlmonline.org/index.php/ajlm/article/view/708

Internet

https://ajlmonline.org/index.php/ajlm/article/view/708

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